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The additional glucagon receptor activation creates a meaningfully different physiological effect

Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)

The Phase 3 TRIUMPH-4 ran for 68 weeks

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